The search for a single uniting topic demonstrates a failure to understand complexity.
In complex systems many different things are all connected (thousands of infinite dimensions of them).
For me, the nearest thing is evolution.
But understanding evolution requires deep study of mathematics, cosmology, geology, chemistry, physics, systems theory, and quite a bit of time out in nature just experiencing the diversity that is life.
It now seems clear beyond any shadow of reasonable doubt that human beings are complex beyond the ability of any human to appreciate in detail, and that demands that we must each over simplify that reality to make what sense of it that we can.
Error and uncertainty must be our eternal companions. Anything less than an acceptance of that demonstrates a dangerous hubris derived from ignorance.
Another contender for an approximation to an answer would be a sort of humility. An acceptance of eternal uncertainty even as we make our best efforts to make our understandings as accurate and useful as we can in any specific context (given all the restrictions of each particular context as to time and energy and information available).