Agree with Erik – the precise mechanism is important.
Woodrow Monte has done a lot of very good science on the dietary model of Alzheimer’s, which works.
Mice fed a diet containing low level methanol develop Alzheimer’s symptoms.
Monte has identified two major dietary contributions to methanol -coming initially from canned vegetable matter – the incidence of Alzheimer’s does seem to track the invention and spread of canned foods, then later the introduction of aspartame as a sweetener – again the timing and incidence matches closely.
The biochemical mechanisms are well characterised.
A bit tough, when added sugar is clearly responsible for most of the diabetes and cancer we see, and the alternative sweetener seems to be responsible for most of the Alzheimer’s. Pandering to that particular evolutionary hack (a liking for sweet things) hasn’t worked out so well for us as a species. And having given up all added sweeteners, I can attest to it taking a bit of will power – to not cheat – ever.
Agree with Alvaro1 that we are on the cusp of removing all disease, and it does seem clear that to do so, we will need to exercise some will power to overcome many of the aspects of our being that worked in the context of our deep evolutionary past but are not at all appropriate to our modern existence.